Recombinant Human IL-23R (C-6His)

Item number: EPT034
Availability: In Stock
$179.00
$179.00
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Size: 10ug
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Recombinant Human IL-23R (C-6His)

Recombinant Human IL-23R (C-6His)

$179.00

Recombinant Human IL-23R (C-6His)

$179.00
Size: 10ug
Description
Recombinant Human Interleukin-23 Receptor is produced by our Mammalian expression system and the target gene encoding Gly24-Asp353 is expressed with a 6His tag at the C-terminus.
Accession
AAM44229.1
Molecular weight
38.7 KDa
Apparent molecular weight
60-90 KDa, reducing conditions
Other names
Interleukin-23 receptor; IL23R; IL-23 receptor; IL-23R
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Biological activity
Immobilized Human IL-23R-His(Cat#CP20) at 5μg/ml (100 μl/well)can bind Human IL-23-Fc (Cat#CW93).The ED50 of Human IL-23-Fc (Cat#CW93) is 0.187 ug/ml.
Redissolve
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Delivery condition
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.

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