Recombinant Mouse Nectin-4 (C-Fc)

Item number: EPT020
Availability: In Stock
$3,209.00
$3,209.00
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Size: 500ug
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Recombinant Mouse Nectin-4 (C-Fc)

Recombinant Mouse Nectin-4 (C-Fc)

$3,209.00

Recombinant Mouse Nectin-4 (C-Fc)

$3,209.00
Size: 500ug
Description
Recombinant Mouse Poliovirus Receptor-Related Protein 4 is produced by our Mammalian expression system and the target gene encoding Gly31-Ile349 is expressed with a Fc tag at the C-terminus.
Accession
Q8R007
Molecular weight
61.4 KDa
Apparent molecular weight
75-85 KDa, reducing conditions
Other names
PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Redissolve
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Delivery condition
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Nectin-4 (PVRL4) is a type I transmembrane glycoprotein which belongs to the nectin family of Ig superfamily proteins. It contains two Ig-like C2-type domains and one Ig-like V-type domain. PVRL4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with nectin-1. It does not act as receptor for alpha-herpesvirus entry into cells. It is predominantly expressed in placenta, the embryo and breast carcinoma. But it is not detected in normal breast epithelium. The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder.

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