Recombinant Mouse Tpsb2 (C-6His)
Vendor: ELK Biotechnology
SKU: EPT037
Regular price
$619.00 USD
Sale price
Regular price
Unit price
/per
Shipping calculated at checkout.
Documents
Available in stock (100)
Request a Quote
✅ Thank you! Your quote request was sent successfully.
❌ Something went wrong. Please check your details and try again.
- Customs clearance fees may apply
- Worldwide shipping available.
Couldn't load pickup availability
For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Accession
P21845
Apparent molecular weight
32-38 KDa, reducing conditions
Delivery condition
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Description
Recombinant Mouse Tryptase Beta-2 is produced by our Mammalian expression system and the target gene encoding Ala22-Ser276 is expressed with a 6His tag at the C-terminus.
Endotoxin
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Molecular weight
29.3 KDa
Other names
Tryptase beta-2; Tryptase-2; Mast cell protease 6; mMCP-6
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Storage
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Background
Background
Tryptase beta-2(Tpsb2), also known as Mast cell protease 6(mMCP-6), belongs to the peptidase S1 family and Tryptase subfamily. Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It plays a role in innate immunity. Tpsb2 can be detected primarily in skin during embryogenesis. Tpsb2 can not be detected at early embryonic stages but is abundantly expressed in later stages with a peak at E17.5-E18.5. Tryptase is a homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.
Documents
Documents
Documents
Product Citations
Product Citations
More Info
More Info
Recombinant Mouse Tpsb2 (C-6His)
Regular price
$619.00 USD
Sale price
Regular price
Unit price
/per
