Strad rabbit pAb

Strad rabbit pAb

Item number: ES3524
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Strad rabbit pAb

Strad rabbit pAb

$148.00

Strad rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human STRAD. AA range:11-60
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
46kD
Geneid human
92335
Human swiss prot no
Q7RTN6
Cellular localization
Nucleus . Cytoplasm .
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009],

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