Product Overview
Product Overview
Applications
WB; ELISA;IHC
Cellular localization
Cell membrane ; Single-pass type I membrane protein. Cell junction . Cell junction, focal adhesion . Cytoplasm, cytoskeleton. Secreted . Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119). Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244). .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
7010
Human swiss prot no
Q02763
Immunogen
The antiserum was produced against synthesized peptide derived from human TIE2 around the phosphorylation site of Tyr1108. AA range:1074-1123
Isotype
IgG
Observed band
150kD
Product weight
0.005kg
Reactivity
Human;Mouse
Recommended dilutions
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Source
Rabbit
Storage
-20°C/1 year
Documents
Documents
Documents
Background
Background
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014],
Product Citations
Product Citations
More Info
More Info
Tie-2 (phospho Tyr1108) rabbit pAb
Tie-2 (phospho Tyr1108) rabbit pAb
Vendor: ELK Biotechnology
SKU: ES7364
Regular price
$148.00 USD
Sale price
$148.00 USD
Regular price
Unit price
/per
Shipping calculated at checkout.
Documents
Available in stock (100)
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB; ELISA;IHC
Cellular localization
Cell membrane ; Single-pass type I membrane protein. Cell junction . Cell junction, focal adhesion . Cytoplasm, cytoskeleton. Secreted . Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119). Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244). .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
7010
Human swiss prot no
Q02763
Immunogen
The antiserum was produced against synthesized peptide derived from human TIE2 around the phosphorylation site of Tyr1108. AA range:1074-1123
Isotype
IgG
Observed band
150kD
Product weight
0.005kg
Reactivity
Human;Mouse
Recommended dilutions
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Source
Rabbit
Storage
-20°C/1 year
Documents
Documents
Documents
Background
Background
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014],
Product Citations
Product Citations
More Info
More Info
Tie-2 (phospho Tyr1108) rabbit pAb
Regular price
$148.00 USD
Sale price
$148.00 USD
Regular price
Unit price
/per
