Acetyl Lys proteins rabbit pAb

Acetyl Lys proteins rabbit pAb

Item number: ES4384
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Acetyl Lys proteins rabbit pAb

Acetyl Lys proteins rabbit pAb

$148.00

Acetyl Lys proteins rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat;Monkey,plant
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
Synthesized acetyl-peptide derived from human acetylation Lys proteins.
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
20,40,80,175kD
Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis. Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport. The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drugs currently in development.

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