Actinin-α1/2/3/4 rabbit pAb

Actinin-α1/2/3/4 rabbit pAb

Item number: ES1593
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Actinin-α1/2/3/4 rabbit pAb

Actinin-α1/2/3/4 rabbit pAb

$148.00

Actinin-α1/2/3/4 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human ACTN1/2/3/4. AA range:21-70
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
75kD
Geneid human
87/88/89/81
Human swiss prot no
P12814/P35609/Q08043/O43707
Cellular localization
Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Cell membrane . Cell junction . Cell projection, ruffle . Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures. .
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

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