Apaf-1 rabbit pAb

Apaf-1 rabbit pAb

Item number: ES4108
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Apaf-1 rabbit pAb

Apaf-1 rabbit pAb

$148.00

Apaf-1 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human APAF1. AA range:501-550
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
135kD
Geneid human
317
Human swiss prot no
O14727
Cellular localization
Cytoplasm .
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

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