APC5 rabbit pAb

APC5 rabbit pAb

Item number: ES1676
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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APC5 rabbit pAb

APC5 rabbit pAb

$148.00

APC5 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
85kD
Geneid human
51433
Human swiss prot no
Q9UJX4
Cellular localization
Nucleus . Cytoplasm, cytoskeleton, spindle .
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],

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