APEX2 rabbit pAb

APEX2 rabbit pAb

Item number: ES18299
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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APEX2 rabbit pAb

APEX2 rabbit pAb

$148.00

APEX2 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human; Mouse
Applications
WB
Source
Rabbit
Recommended dilutions
WB 1:500-2000
Immunogen
Synthesized peptide derived from human APEX2 AA range: 196-246
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
27301
Human swiss prot no
Q9UBZ4
Cellular localization
Nucleus. Cytoplasm. Mitochondrion . Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012],

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