APLP2 (phospho Tyr755) rabbit pAb

APLP2 (phospho Tyr755) rabbit pAb

Item number: ES5795
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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APLP2 (phospho Tyr755) rabbit pAb

APLP2 (phospho Tyr755) rabbit pAb

$148.00

APLP2 (phospho Tyr755) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human APLP2 around the phosphorylation site of Tyr755. AA range:714-763
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
334
Human swiss prot no
Q06481
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Nucleus .
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],

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