ARK-2/3 (phospho Thr236/202) rabbit pAb

ARK-2/3 (phospho Thr236/202) rabbit pAb

Item number: ES7992
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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ARK-2/3 (phospho Thr236/202) rabbit pAb

ARK-2/3 (phospho Thr236/202) rabbit pAb

$148.00

ARK-2/3 (phospho Thr236/202) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human AurB/C around the phosphorylation site of Thr236/202. AA range:201-250
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
9212/6795
Human swiss prot no
Q96GD4/Q9UQB9
Cellular localization
Nucleus . Chromosome . Chromosome, centromere . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Midbody . Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:20929775). Colocalized with gamma tubulin in the midbody (PubMed:17726514). Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC (PubMed:20605920). Colocalized with SIRT2 during cytokinesis with the midbody (PubMed:17726514). Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12 (PubMed
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015],

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