AS160 (phospho-Ser318) rabbit pAb

Item number: ES18241
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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AS160 (phospho-Ser318) rabbit pAb

$148.00

AS160 (phospho-Ser318) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB
Source
Rabbit
Recommended dilutions
WB 1:1000-2000
Immunogen
Synthesized phosho peptide around human AS160 (Ser318)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
145kD
Geneid human
9882
Human swiss prot no
O60343
Cellular localization
Cytoplasm . Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph

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