ASAH3 rabbit pAb

ASAH3 rabbit pAb

Item number: ES8356
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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ASAH3 rabbit pAb

ASAH3 rabbit pAb

$148.00

ASAH3 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
Synthesized peptide derived from ASAH3 . at AA range: 100-180
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
34kD
Geneid human
125981
Human swiss prot no
Q8TDN7
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010],

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