Ataxin-2 rabbit pAb

Ataxin-2 rabbit pAb

Item number: ES1719
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Ataxin-2 rabbit pAb

Ataxin-2 rabbit pAb

$148.00

Ataxin-2 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human ATXN2. AA range:731-780
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
140kD
Geneid human
6311
Human swiss prot no
Q99700
Cellular localization
Cytoplasm .
ataxin 2(ATXN2) Homo sapiens This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The protein is primarily localized to the Golgi apparatus, with deletion of the Golgi and endoplasmic reticulum signals resulting in abnormal subcellular localization. In addition, the N-terminal region contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegener

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