ATF-2 (phospho Ser472) rabbit pAb

ATF-2 (phospho Ser472) rabbit pAb

Item number: ES4803
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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ATF-2 (phospho Ser472) rabbit pAb

ATF-2 (phospho Ser472) rabbit pAb

$148.00

ATF-2 (phospho Ser472) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human ATF-2 around the phosphorylation site of Ser472. AA range:441-490
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
1386
Human swiss prot no
P15336
Cellular localization
Nucleus. Cytoplasm. Mitochondrion outer membrane. Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
activating transcription factor 2(ATF2) Homo sapiens This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014

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