ATF6A rabbit pAb

ATF6A rabbit pAb

Item number: ES18210
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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ATF6A rabbit pAb

ATF6A rabbit pAb

$148.00

ATF6A rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB
Source
Rabbit
Recommended dilutions
WB 1:500-2000
Immunogen
Synthesized peptide derived from human ATF6A AA range: 221-271
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
90kD
Geneid human
22926
Human swiss prot no
P18850
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Translocates from the endoplasmic reticulum to the Golgi, where it is processed. .; [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (PubMed:10564271, PubMed:12782636). THBS4 promotes its nuclear shuttling (By similarity). .
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011],

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