Atg16 rabbit pAb

Atg16 rabbit pAb

Item number: ES6700
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Atg16 rabbit pAb

Atg16 rabbit pAb

$148.00

Atg16 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen
Synthesized peptide derived from Atg16 . at AA range: 60-140
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
70kD
Geneid human
55054
Human swiss prot no
Q676U5
Cellular localization
Cytoplasm . Preautophagosomal structure membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Recruited to omegasomes membranes by WIPI2 (By similarity). Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (By similarity). Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). Upon activation of non-canonical autophagy, recruited to single-membrane endolysosomal compartments (PubMed:29317426). .
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010],

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