Atm (phospho Ser1981) rabbit pAb

Atm (phospho Ser1981) rabbit pAb

Item number: ES8438
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Atm (phospho Ser1981) rabbit pAb

Atm (phospho Ser1981) rabbit pAb

$148.00

Atm (phospho Ser1981) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human; Mouse;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Atm (phospho Ser1981)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
350kD
Geneid human
472
Human swiss prot no
Q13315
Cellular localization
Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. .
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],

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