AZ1 rabbit pAb

AZ1 rabbit pAb

Item number: ES6440
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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AZ1 rabbit pAb

AZ1 rabbit pAb

$148.00

AZ1 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000,WB 1:500-2000
Immunogen
The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
4946
Human swiss prot no
P54368
Cellular localization
nucleus,cytoplasm,cytosol,
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms

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