Bag-3 rabbit pAb
Bag-3 rabbit pAb

Bag-3 rabbit pAb

Item number: ES8054
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Bag-3 rabbit pAb

Bag-3 rabbit pAb

$148.00

Bag-3 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human BAG3. AA range:411-460
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
80kD
Geneid human
9531
Human swiss prot no
O95817
Cellular localization
Nucleus . Cytoplasm . Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920). .
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],

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