BAP1 (phospho-Ser592) rabbit pAb

Item number: ES18098
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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BAP1 (phospho-Ser592) rabbit pAb

$148.00

BAP1 (phospho-Ser592) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB
Source
Rabbit
Recommended dilutions
WB 1:1000-2000
Immunogen
Synthesized phosho peptide around human BAP1 (Ser592)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
80kD
Geneid human
8314
Human swiss prot no
Q92560
Cellular localization
Cytoplasm . Nucleus . Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). .
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013],

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