Bcl-6 (Acetyl Lys379) rabbit pAb

Item number: ES20058
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Bcl-6 (Acetyl Lys379) rabbit pAb

$148.00

Bcl-6 (Acetyl Lys379) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
WB 1:1000-2000 ELISA 1:5000-20000
Immunogen
Synthesized peptide derived from human Bcl-6 (Acetyl Lys379)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
80kD
Geneid human
604
Human swiss prot no
P41182
Cellular localization
Nucleus .
disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.,disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.,disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.,function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.,induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan.,PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.,tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.,

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