BCSC-1 rabbit pAb

BCSC-1 rabbit pAb

Item number: ES1766
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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BCSC-1 rabbit pAb

BCSC-1 rabbit pAb

$148.00

BCSC-1 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human LHR2A. AA range:371-420
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
86kD
Geneid human
4013
Human swiss prot no
O00534
Cellular localization
nucleus,nucleoplasm,
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. Existing as four alternatively spliced isoforms, the gene encoding VWA5A maps to human chromosome 11q24.2.

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