Bestrophin-1 Rabbit pAb

Bestrophin-1 Rabbit pAb

Item number: ES20817
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Bestrophin-1 Rabbit pAb

Bestrophin-1 Rabbit pAb

$148.00

Bestrophin-1 Rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse
Applications
WB;IHC;IF
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen
Synthetic Peptide of Bestrophin-1 AA range: 161-211
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
67kD
Geneid human
7439
Human swiss prot no
O76090
Cellular localization
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane .
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008],

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