Bim (phospho-Ser77)  rabbit pAb

Bim (phospho-Ser77) rabbit pAb

Item number: ES18053
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Bim (phospho-Ser77)  rabbit pAb

Bim (phospho-Ser77) rabbit pAb

$148.00

Bim (phospho-Ser77) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse
Applications
WB
Source
Rabbit
Recommended dilutions
WB 1:1000-2000
Immunogen
Synthesized phosho peptide around human Bim (Ser77)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
22kD
Geneid human
10018
Human swiss prot no
O43521
Cellular localization
Endomembrane system ; Peripheral membrane protein . Associated with intracytoplasmic membranes. .; [Isoform BimEL]: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.; [Isoform BimL]: Mitochondrion.; [Isoform BimS]: Mitochondrion.; [Isoform Bim-alpha1]: Mitochondrion.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013],

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