BRCA2 (phospho Ser3291) rabbit pAb

Item number: ES7289
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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BRCA2 (phospho Ser3291) rabbit pAb

$148.00

BRCA2 (phospho Ser3291) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human BRCA2 (phospho Ser3291)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
385kD
Geneid human
675
Human swiss prot no
P51587
Cellular localization
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with ERCC5/XPG to nuclear foci following DNA replication stress. .
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008],

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