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Btk (phospho-Ser180) rabbit pAb

Item number: ES17943
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Btk (phospho-Ser180) rabbit pAb

$148.00

Btk (phospho-Ser180) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB
Source
Rabbit
Recommended dilutions
WB 1:1000-2000
Immunogen
Synthesized phosho peptide around human Btk (Ser180)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
80kD
Geneid human
695
Human swiss prot no
Q06187
Cellular localization
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013],

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