c-Cbl (phospho-Tyr731) rabbit pAb

c-Cbl (phospho-Tyr731) rabbit pAb

Item number: ES17789
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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c-Cbl (phospho-Tyr731) rabbit pAb

c-Cbl (phospho-Tyr731) rabbit pAb

$148.00

c-Cbl (phospho-Tyr731) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB
Source
Rabbit
Recommended dilutions
WB 1:1000-2000
Immunogen
Synthesized phosho peptide around human c-Cbl (Tyr731)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
100kD
Geneid human
867
Human swiss prot no
P22681
Cellular localization
Cytoplasm. Cell membrane. Cell projection, cilium . Golgi apparatus . Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Cbl proto-oncogene(CBL) Homo sapiens This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016],

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