c-Fos (phospho Ser374) rabbit pAb

c-Fos (phospho Ser374) rabbit pAb

Item number: ES5352
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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c-Fos (phospho Ser374) rabbit pAb

c-Fos (phospho Ser374) rabbit pAb

$148.00

c-Fos (phospho Ser374) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
IHC;IF;WB;ELISA
Source
Rabbit
Recommended dilutions
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Fos around the phosphorylation site of Ser374. AA range:331-380
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
2353
Human swiss prot no
P01100
Cellular localization
Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008],

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