c-Myc (phospho Thr58) rabbit pAb

Item number: ES1290
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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c-Myc (phospho Thr58) rabbit pAb

$148.00

c-Myc (phospho Thr58) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Applications
WB;IHC;IF;IP;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Thr58. AA range:25-74
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
50,(also ~60KD in some samples)
Geneid human
4609
Human swiss prot no
P01106
Cellular localization
Nucleus, nucleoplasm . Nucleus, nucleolus .
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],

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