C4a/b rabbit pAb

C4a/b rabbit pAb

Item number: ES4272
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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C4a/b rabbit pAb

C4a/b rabbit pAb

$148.00

C4a/b rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human C4A/C4B. AA range:721-770
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
180kD
Geneid human
720/721
Human swiss prot no
P0C0L4/P0C0L5
Cellular localization
Secreted. Cell junction, synapse . Cell projection, axon . Cell projection, dendrite .
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided

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