Calregulin rabbit pAb

Calregulin rabbit pAb

Item number: ES1834
Availability: In Stock
$148.00
$148.00
Please hurry! Only 100 left in stock

Documents

Size: 50μL
Subtotal: $148.00
×

Request a Quote

Thank you! We’ll contact you soon.

10 customers are viewing this product

Customized & fast shipping

Terms and Conditions

Calregulin rabbit pAb

Calregulin rabbit pAb

$148.00

Calregulin rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Rat;Monkey
Applications
WB;Flow Cyt;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
WB 1:500-2000;Flow Cyt 1:50-200;IHC-p 1:100-500;IF/ICC 1:100-500;ELISA 1:5000-20000
Immunogen
The antiserum was produced against synthesized peptide derived from human CALR. AA range:21-70
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
48kD
Geneid human
811
Human swiss prot no
P27797
Cellular localization
Endoplasmic reticulum lumen . Cytoplasm, cytosol . Secreted, extracellular space, extracellular matrix . Cell surface . Sarcoplasmic reticulum lumen . Cytoplasmic vesicle, secretory vesicle, Cortical granule . Cytolytic granule . Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity). In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity). .
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its

Related Products

Recently Viewed Products