Calreticulin Rabbit pAb

Calreticulin Rabbit pAb

Item number: EA366
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Calreticulin Rabbit pAb

Calreticulin Rabbit pAb

$148.00

Calreticulin Rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human, Mouse, Rat
Applications
WB
Source
Rabbit
Recommended dilutions
WB 1:500-1,000
Immunogen
Recombinant Protein
Isotype
IgG
Clonality
Polyclonal
Concentration
1mg/mL
Observed band
55kDa
Geneid human
811
Human swiss prot no
P27797
Cellular localization
Cytoplasm, Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted
Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel . Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation .

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