Caspase 2 (p12, Cleaved-Ala348) rabbit pAb

Vendor: ELK Biotechnology

SKU: ES19954

$148.00

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Documents

Manual

Available in stock (100)

Size: 50μL

50μL 100μL

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Product Overview

Applications

WB; ELISA

Clonality

Polyclonal

Concentration

1 mg/ml

Cost per item

74

Geneid human

835

Human swiss prot no

P42575

Immunogen

Synthesized peptide derived from human Caspase 2 (p12, Cleaved-Ala348)

Isotype

IgG

Observed band

12 50kD

Product weight

0.005kg

Reactivity

Human;Rat;Mouse;

Recommended dilutions

WB 1:1000-2000 ELISA 1:5000-20000

Source

Rabbit

Storage

-20°C/1 year

Documents

Manual

Background

alternative products:Isoforms differ in the N- and C-termini,catalytic activity:Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.,PTM:The mature protease can process its own propeptide, but not that of other caspases.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD.,tissue specificity:Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.,

Caspase 2 (p12, Cleaved-Ala348) rabbit pAb