Caspase 4 (p10, Cleaved-Ala290) rabbit pAb

Item number: ES19956
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Caspase 4 (p10, Cleaved-Ala290) rabbit pAb

$148.00

Caspase 4 (p10, Cleaved-Ala290) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human
Applications
WB; ELISA
Source
Rabbit
Recommended dilutions
WB 1:1000-2000 ELISA 1:5000-20000
Immunogen
Synthesized peptide derived from human Caspase 4 (p10, Cleaved-Ala290)
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
10 42kD
Geneid human
837
Human swiss prot no
P49662
Cellular localization
Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion . Inflammasome . Secreted . Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). .
catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit.,tissue specificity:Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.,

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