Caspase-4 rabbit pAb

Caspase-4 rabbit pAb

Item number: ES7703
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Caspase-4 rabbit pAb

Caspase-4 rabbit pAb

$148.00

Caspase-4 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase-4. AA range:75-124
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
45kD
Geneid human
837
Human swiss prot no
P49662
Cellular localization
Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion . Inflammasome . Secreted . Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). .
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],

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