Caspase-8 (phospho Ser347) rabbit pAb

Caspase-8 (phospho Ser347) rabbit pAb

Item number: ES7727
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Caspase-8 (phospho Ser347) rabbit pAb

Caspase-8 (phospho Ser347) rabbit pAb

$148.00

Caspase-8 (phospho Ser347) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Ser347. AA range:313-362
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
55kD
Geneid human
841
Human swiss prot no
Q14790
Cellular localization
Cytoplasm . Nucleus .
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt

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