Caspase-9 (phospho Tyr153) rabbit pAb

Caspase-9 (phospho Tyr153) rabbit pAb

Item number: ES7741
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Caspase-9 (phospho Tyr153) rabbit pAb

Caspase-9 (phospho Tyr153) rabbit pAb

$148.00

Caspase-9 (phospho Tyr153) rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 9 around the phosphorylation site of Tyr153. AA range:119-168
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
46kD
Geneid human
842
Human swiss prot no
P55211
Cellular localization
nucleus,mitochondrion,cytosol,apoptosome,
CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

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