Cathepsin D rabbit pAb

Cathepsin D rabbit pAb

Item number: ES1870
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Cathepsin D rabbit pAb

Cathepsin D rabbit pAb

$148.00

Cathepsin D rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Cathepsin D. AA range:296-345
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
46,30kD
Geneid human
1509
Human swiss prot no
P07339
Cellular localization
Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015],

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