CATL1 (heavy chain, Cleaved-Ala114) rabbit pAb

Vendor: ELK Biotechnology

SKU: ES19961

$148.00

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Documents

Manual

Available in stock (100)

Size: 50μL

50μL 100μL

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Product Overview

Applications

WB; ELISA

Cellular localization

Lysosome . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted, extracellular space . Secreted . Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. .; [Isoform 2]: Nucleus . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520). Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520). .

Clonality

Polyclonal

Concentration

1 mg/ml

Cost per item

74

Geneid human

1514

Human swiss prot no

P07711

Immunogen

Synthesized peptide derived from human CATL1 (heavy chain, Cleaved-Ala114)

Isotype

IgG

Observed band

25 37kD

Product weight

0.005kg

Reactivity

Human;Rat;Mouse;

Recommended dilutions

WB 1:1000-2000 ELISA 1:5000-20000

Source

Rabbit

Storage

-20°C/1 year

Documents

Manual

Background

catalytic activity:Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Dimer of a heavy and a light chain linked by disulfide bonds.,

CATL1 (heavy chain, Cleaved-Ala114) rabbit pAb