CaVα2δ2 Rabbit pAb

CaVα2δ2 Rabbit pAb

Item number: ES20792
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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CaVα2δ2 Rabbit pAb

CaVα2δ2 Rabbit pAb

$148.00

CaVα2δ2 Rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse
Applications
WB;IHC;IF
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen
Synthetic Peptide of CaVα2δ2 AA range: 540-620
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
100-120kD
Geneid human
9254
Human swiss prot no
Q9NY47
Cellular localization
Membrane ; Single-pass type I membrane protein . Colocalizes with CACNA1A in lipid raft fractions. .
calcium voltage-gated channel auxiliary subunit alpha2delta 2(CACNA2D2) Homo sapiens Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to

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