Product Overview
Product Overview
Applications
IHC;IF;ELISA
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Clonality
Polyclonal
Concentration
1 mg/ml
Cost per item
74
Geneid human
920
Human swiss prot no
P01730
Immunogen
The antiserum was produced against synthesized peptide derived from human CD4 around the phosphorylation site of Ser433. AA range:401-450
Isotype
IgG
Product weight
0.005kg
Reactivity
Human;Mouse
Recommended dilutions
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Source
Rabbit
Storage
-20°C/1 year
Documents
Documents
Documents
Backgrond
Backgrond
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010],
Product Citations
Product Citations
More Info
More Info
CD4 (phospho Ser433) rabbit pAb
CD4 (phospho Ser433) rabbit pAb
Vendor: ELK Biotechnology
SKU: ES7987
Regular price
$148.00
Sale price
$148.00
Regular price
Unit price
/per
Shipping calculated at checkout.
Documents
Available in stock (100)
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Product Overview
Product Overview
Applications
IHC;IF;ELISA
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Clonality
Polyclonal
Concentration
1 mg/ml
Cost per item
74
Geneid human
920
Human swiss prot no
P01730
Immunogen
The antiserum was produced against synthesized peptide derived from human CD4 around the phosphorylation site of Ser433. AA range:401-450
Isotype
IgG
Product weight
0.005kg
Reactivity
Human;Mouse
Recommended dilutions
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Source
Rabbit
Storage
-20°C/1 year
Documents
Documents
Documents
Backgrond
Backgrond
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010],
Product Citations
Product Citations
More Info
More Info
CD4 (phospho Ser433) rabbit pAb
Regular price
$148.00
Sale price
$148.00
Regular price
Unit price
/per
