CD40 rabbit pAb

CD40 rabbit pAb

Item number: ES1910
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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CD40 rabbit pAb

CD40 rabbit pAb

$148.00

CD40 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Mouse;Monkey
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human CD40. AA range:228-277
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
30kD
Geneid human
958
Human swiss prot no
P25942
Cellular localization
[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG

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