CDK5 Activator-binding C48 rabbit pAb

CDK5 Activator-binding C48 rabbit pAb

Item number: ES6757
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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CDK5 Activator-binding C48 rabbit pAb

CDK5 Activator-binding C48 rabbit pAb

$148.00

CDK5 Activator-binding C48 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human CDK5RAP2. AA range:251-300
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
55755
Human swiss prot no
Q96SN8
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Golgi apparatus . Cytoplasm . Cytoplasm, cytoskeleton . Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends in the presence of EB1/MAPRE1. Localization to centrosomes versus Golgi apparatus may be cell type-dependent. For instance, in SK-BR-3 and HEK293F cells, localizes to centrosomes but not to the Golgi apparatus (PubMed:29162697). .
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],

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