Cdk6 rabbit pAb

Cdk6 rabbit pAb

Item number: ES8658
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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Cdk6 rabbit pAb

Cdk6 rabbit pAb

$148.00

Cdk6 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Applications
WB;IHC;IF;ELISA
Source
Rabbit
Recommended dilutions
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000
Immunogen
Synthetic peptide from human protein at AA range: 280-325
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
34kD
Geneid human
1021
Human swiss prot no
Q00534
Cellular localization
Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). .
cyclin dependent kinase 6(CDK6) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefS

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