CFAD (Cleaved-Ile26) rabbit pAb

Vendor: ELK Biotechnology

SKU: ES19983

$148.00

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Documents

Manual

Available in stock (100)

Size: 50μL

50μL 100μL

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Product Overview

Applications

WB; ELISA

Cellular localization

Secreted.

Clonality

Polyclonal

Concentration

1 mg/ml

Cost per item

74

Geneid human

1675

Human swiss prot no

P00746

Immunogen

Synthesized peptide derived from human CFAD (Cleaved-Ile26)

Isotype

IgG

Observed band

25kD

Product weight

0.005kg

Reactivity

Human;Rat;Mouse;

Recommended dilutions

WB 1:1000-2000 ELISA 1:5000-20000

Source

Rabbit

Storage

-20°C/1 year

Documents

Manual

Backgrond

catalytic activity:Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.,disease:Defects in CFD are the cause of complement factor D deficiency [MIM:134350]. This deficiency predisposes to invasive meningococcal disease.,function:Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.,online information:CFD mutation db,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,

CFAD (Cleaved-Ile26) rabbit pAb