Product Overview
Product Overview
Applications
WB
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin. Located to spindle poles and microtubules during mitosis. In complex with TACC3 localized to microtubule plus-ends in mitosis and interphase. In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles. Accumulation sites at microtubule plus ends protruded approximately 100 nm from MAPRE1/EB1 sites in interphase cells. .
Clonality
Polyclonal
Concentration
1 mg/ml
Cost per item
74
Geneid human
9793
Human swiss prot no
Q14008
Immunogen
Synthesized peptide derived from human CKAP5 AA range: 1446-1496
Isotype
IgG
Product weight
0.005kg
Reactivity
Human; Mouse
Recommended dilutions
WB 1：500-2000
Source
Rabbit
Storage
-20°C/1 year
Documents
Documents
Documents
Backgrond
Backgrond
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
Product Citations
Product Citations
More Info
More Info
CKAP5 rabbit pAb
CKAP5 rabbit pAb
Vendor: ELK Biotechnology
SKU: ES17422
Regular price
$148.00
Sale price
$148.00
Regular price
Unit price
/per
Shipping calculated at checkout.
Documents
Available in stock (100)
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Product Overview
Product Overview
Applications
WB
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin. Located to spindle poles and microtubules during mitosis. In complex with TACC3 localized to microtubule plus-ends in mitosis and interphase. In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles. Accumulation sites at microtubule plus ends protruded approximately 100 nm from MAPRE1/EB1 sites in interphase cells. .
Clonality
Polyclonal
Concentration
1 mg/ml
Cost per item
74
Geneid human
9793
Human swiss prot no
Q14008
Immunogen
Synthesized peptide derived from human CKAP5 AA range: 1446-1496
Isotype
IgG
Product weight
0.005kg
Reactivity
Human; Mouse
Recommended dilutions
WB 1：500-2000
Source
Rabbit
Storage
-20°C/1 year
Documents
Documents
Documents
Backgrond
Backgrond
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
Product Citations
Product Citations
More Info
More Info
CKAP5 rabbit pAb
Regular price
$148.00
Sale price
$148.00
Regular price
Unit price
/per
