Icotrokinra

Vendor: Abmole

Type: Molecular

SKU: M40707

$310.50 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Icotrokinra (JNJ-77242113, JNJ-2113) is a novel, orally active IL-23R peptide antagonist for studies related to plaque psoriasis. Icotrokinra exhibits high affinity with human IL-23 receptor hIL-23R with a Kd of 7.1 pM. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in PMBCs (IC50=5.6 pM), and inhibits L-23-induced generation of IFNγ and IL-17A in picomolar levels.
Casnumber
2763602-16-8
Formula
C90H120N20O22S2
Mw
1898.17
Psmiles
CC1=C2C(=CC=C1)C(=CN2)CC3C(=O)NC(C(=O)NC(C(SSC(C(C(=O)NC(C(=O)NC(C(=O)N3)C(C)O)CC(=O)N)NC(=O)C)(C)C)(C)C)C(=O)NC(CC4=CC=C(C=C4)OCCN)C(=O)NC(CC5=CC6=CC=CC=C6C=C5)C(=O)NC7(CCOCC7)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CC8=CN=CC=C8)C(=O)N(C)CC(=O)N)CCCCNC(=O)C
Purity
99.22%
Target synonyms
JNJ-2113; JNJ-77242113; PN-235
Icotrokinra

Icotrokinra

$310.50 USD