NPL4 rabbit pAb

Item number: ES9944
Availability: In Stock
$148.00
$148.00
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Size: 50μL
Subtotal: $148.00
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NPL4 rabbit pAb

$148.00

NPL4 rabbit pAb

$148.00
Size: 50μL
Product weight
0.005kg
Reactivity
Human;Rat;Mouse
Applications
WB;ELISA
Source
Rabbit
Recommended dilutions
WB 1:500-2000 ELISA 1:5000-20000
Immunogen
Synthesized peptide derived from human protein . at AA range: 270-350
Isotype
IgG
Clonality
Polyclonal
Concentration
1 mg/ml
Observed band
66kD
Geneid human
55666
Human swiss prot no
Q8TAT6
Cellular localization
Cytoplasm, cytosol . Endoplasmic reticulum . Nucleus . Associated with the endoplasmic reticulum and nuclear. .
domain:Binds ubiquitinated proteins via its RanBP2-type zinc finger.,function:The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway:Protein degradation; proteasomal ubiquitin-dependent pathway.,similarity:Belongs to the NPL4 family.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Associated with the endoplasmic reticulum and nuclear.,subunit:Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.,tissue specificity:Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.,

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